methyl5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate

Base Information

• Chemical Name: methyl5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate
• CAS No.: 1103500-32-8
• Molecular Formula: C₁₅H₁₂F₃NO₄
• Molecular Weight: 327.26
• Mol file: 1103500-32-8.mol

Synonyms:methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate

Chemical Property of methyl5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate

Chemical Property:

• Boiling Point: 379.8±42.0 °C(Predicted)
• PKA: -4.75±0.50(Predicted)
• Density: 1.380±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate

There total 7 articles about methyl5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-hydroxy-2-(trifluoromethoxy)benzimidonyl chloride (543713-03-7) + methyl 3-cyclopropyl-3-oxopropanoate (32249-35-7) → methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate (1103500-32-8)

Guidance literature:

methyl 3-cyclopropyl-3-oxopropanoate; With potassium carbonate; In tetrahydrofuran; for 0.5h; Cooling with ice;

N-hydroxy-2-(trifluoromethoxy)benzimidonyl chloride; In tetrahydrofuran; at 20 ℃; for 77h;

Reference yield: 59.0%

→ methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate (1103500-32-8)

Guidance literature:

With triethylamine; for 0.5h;

In ethanol; at 10 - 30 ℃;

Reference yield: 55.0%

(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride (1383740-01-9) + methyl 3-cyclopropyl-3-oxopropanoate (32249-35-7) → methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate (1103500-32-8)

Guidance literature:

With triethylamine; at -5 ℃;

upstream raw materials:

2-(trifluoromethoxy)benzaldehyde

(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride

methyl 3-cyclopropyl-3-oxopropanoate

(E)-2-(trifluoromethoxy)benzaldehyde oxime

Downstream raw materials:

4-(bromomethyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole

methyl-2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid

methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylate