(1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid

Base Information

• Chemical Name: (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid
• CAS No.: 1428579-86-5
• Molecular Formula: C₃₀H₄₄O₆Si₂
• Molecular Weight: 556.847
• Mol file: 1428579-86-5.mol

Synonyms:(1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid

Chemical Property of (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid

There total 7 articles about (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-3-(4'-((tert-butyldimethylsilyl)oxy)phenyl)acrylic acid (141222-28-8) → (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid (1428579-86-5)

Guidance literature:

for 96h; UV-irradiation;

DOI:10.1016/j.ejmech.2018.04.050

Reference yield: 70.0%

4-tert-butyldimethylsilyloxicinnamic acid (848251-51-4) → (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid (1428579-86-5)

Guidance literature:

In hexane; at 20 ℃; for 60h; Irradiation;

DOI:10.1039/c3cc41811a

Reference yield:

p-Coumaric Acid (7400-08-0,50940-26-6) → (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid (1428579-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 48 h / 0 - 20 °C

2: hexane / 60 h / Irradiation

With triethylamine; In hexane; dichloromethane;

DOI:10.1016/j.bmcl.2013.01.091

upstream raw materials:

4-hydroxy-benzaldehyde

p-Coumaric Acid

(E)-3-(4'-((tert-butyldimethylsilyl)oxy)phenyl)acrylic acid

para-coumaric acid

Downstream raw materials:

C₄₄H₆₈O₆Si₂

C₄₀H₆₀O₈Si₂

C₃₄H₄₈O₆Si₂

C₄₀H₆₀O₈Si₂