2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI)

Base Information

Chemical Name:2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI)
CAS No.:283594-71-8
Molecular Formula:C₉H₁₇NO₂
Molecular Weight:171.239
Hs Code.:
Mol file:283594-71-8.mol

Synonyms:2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI)

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Chemical Property of 2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI)

Chemical Property:

PSA：38.33000
LogP:2.10420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI)

There total 5 articles about 2H-1,3-Oxazin-2-one,tetrahydro-4,6-dimethyl-5-(1-methylethyl)-,(4R,5R,6S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 283594-58-1
(+)-(4S,5R,6S)-tetrahydro-6-methyl-5-(1-methylethyl)-4-{[(S)-N-methyl-S-phenylsulfonimidoyl]methyl}-2H-1,3-oxazin-2-one

: 283594-71-8
(-)-(4R,5R,6S)-tetrahydro-4,6-dimethyl-5-(1-methylethyl)-2H-1,3-oxazin-2-one

Guidance literature:: nickel; In tetrahydrofuran; water; at 22 ℃;
DOI:10.1016/S0040-4039(00)00307-5

Reference yield: 85.0%

: 75-07-0,9002-91-9
acetaldehyde

: 283594-58-1
(+)-(4S,5R,6S)-tetrahydro-6-methyl-5-(1-methylethyl)-4-{[(S)-N-methyl-S-phenylsulfonimidoyl]methyl}-2H-1,3-oxazin-2-one

: 283594-71-8
(-)-(4R,5R,6S)-tetrahydro-4,6-dimethyl-5-(1-methylethyl)-2H-1,3-oxazin-2-one

: (4R,5R,6S)-tetrahydro-6-methyl-5-(1-methylethyl)-4-(1-propenyl)-2H-1,3-oxazin-2-one

Guidance literature:: acetaldehyde; (+)-(4S,5R,6S)-tetrahydro-6-methyl-5-(1-methylethyl)-4-{[(S)-N-methyl-S-phenylsulfonimidoyl]methyl}-2H-1,3-oxazin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 7h;

With aluminium amalgam; In tetrahydrofuran; water; acetic acid; at 20 ℃; for 2h;
DOI:10.1002/ejoc.200390210

Reference yield:

: 283594-52-5
(-)-(Z)-(2S,3R)-3-isopropyl-5-[(S)-N-methyl-S-phenylsulfonimidoyl]pent-4-en-2-ol

: 283594-71-8
(-)-(4R,5R,6S)-tetrahydro-4,6-dimethyl-5-(1-methylethyl)-2H-1,3-oxazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / 20 °C

1.2: 90 percent / aq. NH₃ / 1 h / 20 °C

2.1: 94 percent / nBuLi / tetrahydrofuran; hexane / 18 h / -78 - 20 °C

3.1: 88 percent / Raney nickel / tetrahydrofuran; H₂O / 5.5 h / 20 °C

With n-butyllithium; nickel; In tetrahydrofuran; hexane; water;
DOI:10.1002/ejoc.200390210