1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester
CAS No.:853070-90-3
Molecular Formula:C₂₂H₁₄F₂O₆
Molecular Weight:412.346
Hs Code.:

Synonyms:1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

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Chemical Property of 1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

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Technology Process of 1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

There total 6 articles about 1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 853070-71-0
1-hydroxydibenzofuran-4,6-dicarboxylic acid dimethyl ester

: 156545-07-2
3,5-difluorophenylboronic acid

: 853070-90-3
1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

Guidance literature:: With pyridine; 4 A molecular sieve; copper diacetate; In dichloromethane;
DOI:10.1021/ja044351f

Reference yield:

: 853070-69-6
(dibenzofuran-1-yloxy)triisopropylsilane

: 853070-90-3
1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sec-butyllithium; TMEDA / diethyl ether; cyclohexane / -78 - 20 °C

1.2: diethyl ether; cyclohexane / 0.5 h / -78 °C

2.1: 0.36 g / methanol; benzene; hexane

3.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: 93 percent / copper (II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂

With pyridine; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; tetrabutyl ammonium fluoride; sec.-butyllithium; copper diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; benzene;
DOI:10.1021/ja044351f

Reference yield:

: 75116-26-6
9b-bromo-2,4,6,8-tetra-tert-butyl-9bH-dibenzofuran-1-one

: 853070-90-3
1-(3,5-difluorophenoxy)dibenzofuran-4,6-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: AlCl₃ / toluene

2.1: 77 percent / DMAP / CH₂Cl₂

3.1: sec-butyllithium; TMEDA / diethyl ether; cyclohexane / -78 - 20 °C

3.2: diethyl ether; cyclohexane / 0.5 h / -78 °C

4.1: 0.36 g / methanol; benzene; hexane

5.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: 93 percent / copper (II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂

With pyridine; dmap; aluminium trichloride; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; tetrabutyl ammonium fluoride; sec.-butyllithium; copper diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; toluene; benzene;
DOI:10.1021/ja044351f