((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

Base Information

Chemical Name:((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride
CAS No.:1368855-98-4
Molecular Formula:C₁₂H₁₅FN₂O₅S
Molecular Weight:318.326
Hs Code.:

Synonyms:((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

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Chemical Property of ((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

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Technology Process of ((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

There total 6 articles about ((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1367876-83-2
tert-butyl ((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)carbamate

: 1368855-98-4
((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 - 40 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm300069y

Reference yield:

: C₂₁H₂₅FN₂O₇S

: 1368855-98-4
((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere

1.2: 3 h / 25 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

3.1: Chiralpak AD-I / ethanol; hexane; dichloromethane; isopropyl alcohol / Inert atmosphere

4.1: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 25 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 25 - 40 °C / Inert atmosphere

With morpholine; hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium peroxymonosulfate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm300069y

Reference yield:

: tert-butyl ((3RS,5SR)-5-(3-fluoro-4-nitrobenzyl)-4-oxotetrahydro-2H-thiopyran-3-yl)carbamate

: 1368855-98-4
((3R,4S,5S)-5-(3-fluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-hydro-2H-thiopyran-3-yl)hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

2: Chiralpak AD-I / ethanol; hexane; dichloromethane; isopropyl alcohol / Inert atmosphere

3: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 25 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 25 - 40 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; potassium peroxymonosulfate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm300069y