(3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate

Base Information

• Chemical Name: (3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate
• CAS No.: 1426302-87-5
• Molecular Formula: C₂₁H₁₈O₄
• Molecular Weight: 334.372
• Mol file: 1426302-87-5.mol

Synonyms:(3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate

Chemical Property of (3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate

There total 1 articles about (3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2,2-diphenylacetic acid (117-34-0) + 3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one (139367-24-1,139491-15-9,141554-44-1,148555-09-3,148555-10-6) → (3R,3aR,6aS)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate (1426302-87-5) + (3S,3aS,6aR)-3,3a,4,6a-tetrahydro-2-oxo-2H-cyclopenta[b]furan-3-yl 2,2-diphenylacetate + (3S,3aR,6aR)-3-hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one (151765-22-9)

Guidance literature:

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; at 20 ℃; for 12h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol303453j

upstream raw materials:

2,2-diphenylacetic acid

3-hydroxy-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one