2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

Base Information

Chemical Name:2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride
CAS No.:1165923-27-2
Molecular Formula:C₂₁H₂₀N₄O₂*ClH
Molecular Weight:396.876
Hs Code.:

Synonyms:2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

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Chemical Property of 2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

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Technology Process of 2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

There total 6 articles about 2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1165923-65-8
1,1-dimethylethyl 5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1165923-27-2
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 64h;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1165923-27-2
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

2: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 - 95 °C

3: hydrogenchloride / 1,4-dioxane / 64 h / 20 °C

With hydrogenchloride; dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336

Reference yield:

: 601514-57-2
tert-butyl 5-cyano-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1165923-27-2
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 24 h / 65 °C

2: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 - 95 °C

3: hydrogenchloride / 1,4-dioxane / 64 h / 20 °C

With hydrogenchloride; dmap; hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336