(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

Base Information

Chemical Name:(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide
CAS No.:1311378-56-9
Molecular Formula:C₂₁H₂₀F₃NO₂
Molecular Weight:375.391
Hs Code.:

Synonyms:(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

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Chemical Property of (E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

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Technology Process of (E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

There total 4 articles about (E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311378-42-3
(E)-4-(trifluoromethyl)benzaldehyde O-[1-(4-methoxyphenyl)-4-methylpent-1-yn-3-yl]oxime

: 1311378-56-9
(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

: (Z)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

Guidance literature:: With [CuCl(cod)]2; In acetonitrile; at 100 ℃; for 25h; optical yield given as %de; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol2012583

Reference yield:

: C₂₁H₁₉NO₄

: 1311378-56-9
(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

: (Z)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 2 h / 65 °C

3: [CuCl(cod)]2 / acetonitrile / 25 h / 100 °C / Inert atmosphere

With [CuCl(cod)]2; hydrazine hydrate; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0031-1290819

Reference yield:

: 1388625-07-7
C₁₃H₁₇NO₂

: 1311378-56-9
(E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

: (Z)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 65 °C

2: [CuCl(cod)]2 / acetonitrile / 25 h / 100 °C / Inert atmosphere

With [CuCl(cod)]2; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0031-1290819