Technology Process of D-(p-hydroxyphenyl)glycine-L-acetylserine-L-(p-hydroxyphenyl)glycylpantetheine trifluoroacetate
There total 14 articles about D-(p-hydroxyphenyl)glycine-L-acetylserine-L-(p-hydroxyphenyl)glycylpantetheine trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid;
In
acetonitrile;
at 20 ℃;
for 0.25h;
DOI:10.1021/jo4007893
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / water; tetrahydrofuran / 12 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C
2.2: 3 h / 0 - 20 °C
3.1: pyridine / 12 h / 20 °C
4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 2585.81 Torr
5.1: potassium carbonate; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
6.1: trifluoroacetic acid; water / acetonitrile / 0.25 h / 20 °C
With
pyridine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; 10 wt% Pd(OH)2 on carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo4007893
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C
2.2: 3 h / 0 - 20 °C
3.1: pyridine / 12 h / 20 °C
4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 12 h / 2585.81 Torr
5.1: potassium carbonate; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
6.1: trifluoroacetic acid; water / acetonitrile / 0.25 h / 20 °C
With
pyridine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; 10 wt% Pd(OH)2 on carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo4007893
