(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

Base Information

Chemical Name:(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol
CAS No.:1390644-09-3
Molecular Formula:C₄₈H₆₂O₇Si₂
Molecular Weight:807.187
Hs Code.:

Synonyms:(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

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Chemical Property of (1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

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Technology Process of (1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

There total 6 articles about (1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1390644-06-0
(E)-(2-(benzyloxy)-4-(3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)prop-1-en-1-yl)phenoxy)(tert-butyl)dimethylsilane

: 1390644-09-3
(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

Guidance literature:: With methanesulfonamide; AD-mix-α; In dichloromethane; water; tert-butyl alcohol; at 0 - 20 ℃; for 72h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol3016463

Reference yield:

: 889471-78-7
(E)-2-(benzyloxy)-4-(3-hydroxyprop-1-en-1-yl)phenol

: 1390644-09-3
(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Montmorillonite K-10 clay / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 13.5 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

3.1: AD-mix-α; methanesulfonamide / dichloromethane; water; tert-butyl alcohol / 72 h / 0 - 20 °C / Inert atmosphere

With methanesulfonamide; AD-mix-α; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; tert-butyl alcohol; 1.1: Friedel Crafts alkylation / 1.2: Friedel Crafts alkylation;
DOI:10.1021/ol3016463

Reference yield:

: 1006589-37-2
(E)-ethyl 3-(3-benzyloxy-4-hydroxyphenyl)acrylate

: 1390644-09-3
(1S,2S)-1-(3-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)phenyl)-3-(2,4-bis(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)phenyl)propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene / 2.5 h / -78 - 20 °C / Inert atmosphere

2.1: Montmorillonite K-10 clay / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 13.5 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

4.1: AD-mix-α; methanesulfonamide / dichloromethane; water; tert-butyl alcohol / 72 h / 0 - 20 °C / Inert atmosphere

With methanesulfonamide; AD-mix-α; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; toluene; tert-butyl alcohol; 2.1: Friedel Crafts alkylation / 2.2: Friedel Crafts alkylation;
DOI:10.1021/ol3016463