1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

Base Information

Chemical Name:1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone
CAS No.:1352548-29-8
Molecular Formula:C₂₅H₂₃NO₃S
Molecular Weight:417.529
Hs Code.:

Synonyms:1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

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Chemical Property of 1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

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Technology Process of 1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

There total 6 articles about 1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1352548-16-3
4-methyl-N-(2-[5-(4-methylbenzyl)-2-furyl]phenyl)benzenesulfonamide

: 1352548-29-8
1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

Guidance literature:: With perchloric acid; acetic acid; In water; Reflux;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 1352548-07-2
C₁₈H₁₅NO₃

: 1352548-29-8
1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: pyridine / 12 h / 0 - 20 °C

3: perchloric acid; acetic acid / water / Reflux

With pyridine; perchloric acid; hydrazine hydrate; acetic acid; In ethanol; water;
DOI:10.1016/j.tet.2011.10.114

Reference yield:

: 1352548-36-7
[5-(2-nitrophenyl)-2-furyl](p-tolyl)methanone

: 1352548-29-8
1-(4-methylphenyl)-3-(1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / -10 °C / Reflux

2: hydrazine hydrate / ethanol / 2 h / Reflux

3: pyridine / 12 h / 0 - 20 °C

4: perchloric acid; acetic acid / water / Reflux

With pyridine; aluminum (III) chloride; sodium tetrahydroborate; perchloric acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.tet.2011.10.114