N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Base Information

Chemical Name:N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
CAS No.:1356145-41-9
Molecular Formula:C₁₇H₁₃FN₆O₄S
Molecular Weight:416.392
Hs Code.:

Synonyms:N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

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Chemical Property of N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

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Technology Process of N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

There total 10 articles about N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₈FN₅

: 121-02-8
2-methyl-5-nitrobenzene-1-sulfonyl chloride

: 1356145-41-9
N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: With sodium hydrogencarbonate; In methanol; for 0.5h;
DOI:10.1016/j.bmc.2011.11.029

Reference yield:

: 1356145-04-4
6-fluoropyrazolo[1,5-a]pyridine-5-carboxamide

: 1356145-41-9
N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

1.2: pH 10

2.1: trichlorophosphate / 2 h / 20 °C / Inert atmosphere

2.2: pH 10

3.1: sodium hydrogencarbonate / methanol

4.1: sodium hydrogencarbonate / methanol / 0.5 h

With sodium hydrogencarbonate; trichlorophosphate; In methanol; N,N-dimethyl-formamide; 2.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.11.029

Reference yield:

: 1356144-38-1
ethyl 5-(1,3-dioxolan-2-yl)-6-fluoropyrazolo[1,5-a]pyridine-3-carboxylate

: 1356145-41-9
N'-((5-cyano-6-fluoropyrazolo[1,5-a]pyridin-3-yl)-methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: perchloric acid / 1,4-dioxane; acetone / 3 h

2.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / water; acetonitrile / 3 h / 20 °C

3.1: sulfuric acid; water / 18 h / Reflux

3.2: pH 7

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h

4.2: 0.5 h

5.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

5.2: pH 10

6.1: trichlorophosphate / 2 h / 20 °C / Inert atmosphere

6.2: pH 10

7.1: sodium hydrogencarbonate / methanol

8.1: sodium hydrogencarbonate / methanol / 0.5 h

With sodium chlorite; sodium dihydrogenphosphate; perchloric acid; sulfuric acid; water; dihydrogen peroxide; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; 6.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.11.029