methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

Base Information

Chemical Name:methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate
CAS No.:1201823-22-4
Molecular Formula:C₃₁H₃₂ClF₃N₂O₆
Molecular Weight:621.053
Hs Code.:

Synonyms:methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

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Chemical Property of methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

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Technology Process of methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

There total 1 articles about methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1091600-50-8
methyl 4-{2-[6-(bromomethyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 561304-42-5
tert-butyl N-[3-(trifluoromethoxy)phenyl]carbamate

: 1201823-22-4
methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: tert-butyl N-[3-(trifluoromethoxy)phenyl]carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Cooling with ice;

methyl 4-{2-[6-(bromomethyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1201823-22-4
methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 1201823-23-5
4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid

Guidance literature:: methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 65 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1201823-22-4
methyl 4-{2-[6-({(tert-butoxycarbonyl)[3-(trifluoromethoxy)phenyl]amino}methyl)-3-chloro-5-cyclopropyl-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 1201818-54-3
4-{2-[3-chloro-5-cyclopropyl-2-oxo-6-({[3-(trifluoromethoxy)phenyl]amino}methyl)pyridin-1(2H)-yl]ethyl}benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 65 °C

2: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate;