1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone

Base Information

• Chemical Name: 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone
• CAS No.: 3162-33-2
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.284
• Mol file: 3162-33-2.mol

Synonyms:1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone

Chemical Property of 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone

There total 1 articles about 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

Sesamol (533-31-3) + p-methoxybenzylnitrile (104-47-2) → 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone (3162-33-2)

Guidance literature:

Sesamol; p-methoxybenzylnitrile; With hydrogenchloride; zinc(II) chloride; In diethyl ether; at 0 - 20 ℃;

With sulfuric acid; water; In diethyl ether; for 2h; Reflux;

DOI:10.1002/ejoc.201801171

Reference yield: 68.0%

1,4-dioxane-2,6-dione (4480-83-5) + 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone (3162-33-2) → {[7-(4-methoxyphenyl)-8-oxo-8H-[1,3]dioxolo[4,5-g]chromen-6-yl]methoxy}acetic acid

Guidance literature:

1,4-dioxane-2,6-dione; 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone; With triethylamine; In 1,4-dioxane; at 100 ℃; for 0.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 100 ℃;

With sulfuric acid; In 1,4-dioxane; water; at 80 ℃;

DOI:10.1002/ejoc.201801171

Reference yield: 52.0%

glutaric anhydride, (108-55-4) + 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone (3162-33-2) → 4-[7-(4-methoxyphenyl)-8-oxo-8H-[1,3]dioxolo[4,5-g]chromen-6-yl]butanoic acid

Guidance literature:

glutaric anhydride,; 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-(4-methoxyphenyl)ethanone; With triethylamine; In 1,4-dioxane; at 100 ℃; for 0.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 100 ℃;

With sulfuric acid; In 1,4-dioxane; water; at 80 ℃;

DOI:10.1002/ejoc.201801171

upstream raw materials:

Sesamol

p-methoxybenzylnitrile