3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Base Information

Chemical Name:3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile
CAS No.:1309431-04-6
Molecular Formula:C₁₅H₇ClF₂N₄O
Molecular Weight:332.697
Hs Code.:

Synonyms:3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

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Chemical Property of 3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

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Technology Process of 3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

There total 5 articles about 3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309431-03-5
4-chloro-3-(2,6-difluoro-3-nitro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1309431-04-6
3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Guidance literature:: 4-chloro-3-(2,6-difluoro-3-nitro-benzoyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; With tin(ll) chloride; In tetrahydrofuran; ethanol; at 60 ℃; for 24h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

Reference yield:

: 260552-98-5
2,6-difluoro-3-nitrobenzoic acid chloride

: 1309431-04-6
3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / 96 h / 0 - 20 °C

2: tin(ll) chloride / ethanol; tetrahydrofuran / 24 h / 60 °C

With trifluorormethanesulfonic acid; tin(ll) chloride; In tetrahydrofuran; ethanol;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1309431-04-6
3-(3-amino-2,6-difluoro-benzoyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 80 °C

2: trifluorormethanesulfonic acid / 96 h / 0 - 20 °C

3: tin(ll) chloride / ethanol; tetrahydrofuran / 24 h / 60 °C

With thionyl chloride; trifluorormethanesulfonic acid; tin(ll) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;