5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Chemical Name:5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
CAS No.:1570043-20-7
Molecular Formula:C₂₅H₂₄F₃N₅O₂S
Molecular Weight:515.559
Hs Code.:

Synonyms:5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Technology Process of 5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

There total 7 articles about 5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 56935-71-8
N-hydroxy-4-(trifluoromethoxy)benzimidamide

: 1570043-23-0
4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazole-2-carboxylic acid

: 1570043-20-7
5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: 4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazole-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-hydroxy-4-(trifluoromethoxy)benzimidamide; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 3h;

Reference yield:

: 332-25-2
4-(trifluoromethoxy)benzonitrile

: 1570043-20-7
5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; hydroxylamine hydrochloride / ethanol / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 3 h / 20 - 140 °C

With hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 932-77-4
3-bromobenzyl chloride

: 1570043-20-7
5-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ethanol / 20 °C / Reflux

2.1: copper(ll) bromide / chloroform; ethyl acetate / 2 h / Reflux

3.1: ethanol / Reflux

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / Inert atmosphere; Reflux

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 3 h / 20 - 140 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(ll) bromide; lithium hydroxide; XPhos; In tetrahydrofuran; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;