8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

Base Information

Chemical Name:8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine
CAS No.:186808-54-8
Molecular Formula:C₂₂H₂₇N₅O₄S
Molecular Weight:457.553
Hs Code.:

Synonyms:8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

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Chemical Property of 8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

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Technology Process of 8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

There total 6 articles about 8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 4318-37-0
1-Methylhomopiperazine

: 186808-53-7
8-chloroacetyl-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-54-8
8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

Guidance literature:: With potassium iodide; In acetonitrile; for 24h; Heating;
DOI:10.3987/COM-98-8179

Reference yield:

: 186808-51-5
4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-54-8
8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: KI

With triethylamine; potassium iodide;
DOI:10.1021/jm030287l

Reference yield:

: 213678-61-6
5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

: 186808-54-8
8-(4-methyl-hexahydro-1H-<1,4>diazepin-1-ylacetyl)-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-b><1,4>diazepine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 74.8 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

3: 83.4 percent / KI / acetonitrile / 24 h / Heating

With triethylamine; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.3987/COM-98-8179