4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol

Base Information

• Chemical Name: 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol
• CAS No.: 1245635-41-9
• Molecular Formula: C₁₆H₂₇BO₃Si
• Molecular Weight: 306.285
• Mol file: 1245635-41-9.mol

Synonyms:4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol

Chemical Property of 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol

There total 1 articles about 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-hydroxy-5-methyl-3-(trimethylsilyl)phenyl]boronic acid + 2,3-dimethyl-2,3-butane diol (76-09-5) → 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol (1245635-41-9)

Guidance literature:

In dichloromethane; Inert atmosphere;

DOI:10.1002/anie.201002191

Reference yield: 71.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol (1245635-41-9) → 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenyl trifluoromethanesulfonate (1245635-42-0)

Guidance literature:

4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenol; With tert.-butyl lithium; In diethyl ether; at -78 ℃; for 0.166667h; Inert atmosphere;

trifluoromethylsulfonic anhydride; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201002191

upstream raw materials:

2,3-dimethyl-2,3-butane diol

Downstream raw materials:

4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trimethylsilyl)phenyl trifluoromethanesulfonate