((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Name:((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1416718-21-2
Molecular Formula:C₃₉H₄₉FN₈O₈
Molecular Weight:776.865
Hs Code.:

((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Synonyms:((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 4 articles about ((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.8%

: 1228553-33-0
[(S)-2-methyl-1-((S)-2-{5-[4-(4,4,5,5 tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester

: 1416718-40-5
((S)-1-{(S)-2-[3-(4-bromo-2-fluoro-phenyl)-ureidocarbonyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 1416718-21-2
((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 85 ℃; for 5h; Inert atmosphere; Sealed vessel;

Reference yield:

: 35150-07-3
(S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate

: 1416718-21-2
((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 4 h / 135 °C / Sealed vessel

2: hydrogenchloride / ethyl acetate; diethyl ether / 20 °C

3: triethylamine / HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 5 h / 85 °C / Inert atmosphere; Sealed vessel

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; HATU; In 1,2-dimethoxyethane; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 88112-75-8
4-bromo-2-fluorophenyl isocyanate

: 1416718-21-2
((S)-1-{(S)-2-[5-(3'-Fluoro-4'-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 4 h / 135 °C / Sealed vessel

2: hydrogenchloride / ethyl acetate; diethyl ether / 20 °C

3: triethylamine / HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 5 h / 85 °C / Inert atmosphere; Sealed vessel

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; HATU; In 1,2-dimethoxyethane; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; toluene;