(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

Base Information

Chemical Name:(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide
CAS No.:228113-65-3
Molecular Formula:C₂₆H₃₇NO₄S
Molecular Weight:459.65
Hs Code.:

Synonyms:(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

Suppliers and Price of (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 17 raw suppliers

Chemical Property of (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

Chemical Property:

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

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Technology Process of (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

There total 1 articles about (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 228113-64-2
3,3-dibutyl-7-dimethylamino-5-(4-methoxy-phenyl)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1λ⁶-benzo[b]thiepin-4-ol

: 228113-65-3
(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

Guidance literature:: With boron tribromide; In dichloromethane; at -5 - 0 ℃; for 1h;
DOI:10.1021/jm0402162

Reference yield: 93.0%

: [(5-bromo-pentyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

: 228113-65-3
(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

: (carboxymethyl-{5-[4-(3,3-dibutyl-7-dimethylamino-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-1λ⁶-benzo[b]thiepin-5-yl)-phenoxy]-pentyl}-amino)-acetic acid

Guidance literature:: (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃;

[(5-bromo-pentyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester; In N,N-dimethyl-formamide; at -10 - 20 ℃;

With lithium hydroxide; water; In tetrahydrofuran; at 40 ℃; for 18h;
DOI:10.1021/jm0402162

Reference yield:

: 228113-65-3
(+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide

: 5-[4-(3,3-dibutyl-7-dimethylamino-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-1λ⁶-benzo[b]thiepin-5-yl)-phenoxy]-pentanoic acid

Guidance literature:: (+)-(4R,5R)-3,3-dibutyl-7-(dimethylamino)-5-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzothiepin-4-ol 1,1-dioxide; With sodium hydride; In N,N-dimethyl-formamide; at -10 ℃;

HO₂C(CH₂)4-halide; In N,N-dimethyl-formamide; at -10 - 20 ℃;
DOI:10.1021/jm0402162