diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

Base Information

Chemical Name:diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate
CAS No.:231295-10-6
Molecular Formula:C₂₅H₂₄ClNO₇
Molecular Weight:485.921
Hs Code.:

Synonyms:diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

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Chemical Property of diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

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Technology Process of diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

There total 4 articles about diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 231295-09-3
(6-chloro-1H-indol-2-yl)(2-methylphenyl)methanone

: 231295-10-6
diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

Guidance literature:

Reference yield:

: 17422-33-2
6-chloroindole

: 231295-10-6
diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / water; benzene / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.75 h / -78 °C / Inert atmosphere

2.2: 2.75 h / -78 - 0 °C / Inert atmosphere

3.1: potassium carbonate; water / tetrahydrofuran; methanol / 14 h / Reflux; Inert atmosphere

4.1: acetic acid; manganese(III) triacetate dihydrate / 2.08 h / 20 - 80 °C / Inert atmosphere

With water; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; manganese(III) triacetate dihydrate; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; water; pentane; benzene;
DOI:10.3109/14756366.2013.864650

Reference yield:

: 231295-53-7
6-chloro-1-(phenylsulfonyl)indole

: 231295-10-6
diethyl 2-acetoxy-2-[6-chloro-2-(2-methylbenzoyl)-1H-indol-3-yl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.75 h / -78 °C / Inert atmosphere

1.2: 2.75 h / -78 - 0 °C / Inert atmosphere

2.1: potassium carbonate; water / tetrahydrofuran; methanol / 14 h / Reflux; Inert atmosphere

3.1: acetic acid; manganese(III) triacetate dihydrate / 2.08 h / 20 - 80 °C / Inert atmosphere

With water; tert.-butyl lithium; manganese(III) triacetate dihydrate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; pentane;
DOI:10.3109/14756366.2013.864650