(+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate

Base Information

• Chemical Name: (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate
• CAS No.: 219635-84-4
• Molecular Formula: C₁₆H₂₀N₂O₅
• Molecular Weight: 320.345
• Mol file: 219635-84-4.mol

Synonyms:(+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate

Chemical Property of (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate

There total 1 articles about (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methyl N-((benzyloxy)carbonyl)-3-iodo-L-alaninate (56877-38-4) + 2-phenylthiomethylacrylamide (135056-66-5) → (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate (219635-84-4)

Guidance literature:

With copper; zinc; In ethanol; for 7h; Ambient temperature;

DOI:10.1080/07328319808004308

Reference yield: 67.0%

methyl 5-deoxy-5-iodo-2,3-isopropylidene-β-D-ribofuranoside (38838-06-1) + (+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate (219635-84-4) → methyl [10-(benzyloxycarbonyl)amino-7-carboxamido-5,6,7,8,9,10-hexadeoxy-2,3-O-(isopropylidene)-10-methoxycarbonyl]-β-D-decaribofuranose

Guidance literature:

With copper(l) iodide; zinc; In tetrahydrofuran; water;

Reference yield: 20.0%

(+)-methyl 2-N-benzyloxycarbonylamino-5-carboxamidohex-5-enate (219635-84-4) + (+)-N6-triphenylphosphinimino-(4'α-iodo-2'α,3'α-O-isopropylidendioxycyclopent-1'β-yl)-9-H-adenine (219635-80-0) → N6-triphenylphosphinimino-(2'α-hydroxy-3'-cyclopenten-1'-yl)-9-H-adenine + N6-triphenylphosphinimino-<2'α,3'α-O-isopropylidendioxy-4'-(5''S-benzyloxycarbonylamino)-2''(S)-carboxamido-5''-S-(methoxycarbonylpent-1''-yl)-cyclopent-1'-β-yl>-9-H-adenine + N6-triphenylphosphinimino-<2'α,3'α-O-isopropylidendioxy-4'-(5''S-benzyloxycarbonylamino)-2''(R)-carboxamido-5''-S-(methoxycarbonylpent-1''-yl)-cyclopent-1'-β-yl>-9-H-adenine + N6-triphenylphosphinimino-<2'α,3'α-O-isopropylidendioxy-4'-(5''S-benzyloxycarbonylamino)-2''(S)-carboxamido-5''-S-(methoxycarbonylpent-1''-yl)-cyclopent-1'-β-yl>-9-H-adenine

Guidance literature:

With copper; zinc; In ethanol; for 7h; Further byproducts given; Ambient temperature;

DOI:10.1080/07328319808004308

upstream raw materials:

methyl N-((benzyloxy)carbonyl)-3-iodo-L-alaninate

2-phenylthiomethylacrylamide