N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

Base Information

Chemical Name:N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine
CAS No.:934736-49-9
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

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Chemical Property of N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

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Technology Process of N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

There total 7 articles about N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

: 934736-48-8
N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine methyl ester

: 934736-49-9
N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

Guidance literature:: N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine methyl ester; With lithium hydroxide; In methanol; water; N,N-dimethyl-formamide; at 70 ℃; for 3h;

With hydrogenchloride; In methanol; water; N,N-dimethyl-formamide; pH=3;
DOI:10.1016/j.bmc.2012.02.003

Reference yield:

: 934736-46-6
N-butyryl-N-[(2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl]-L-valine methyl ester

: 934736-49-9
N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / N,N-dimethyl-formamide / 2 h / Cooling with ice

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

3.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide / 3 h / 70 °C

3.2: pH 3

With pyridine; lithium hydroxide; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.003

Reference yield:

: 137863-89-9
N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester

: 934736-49-9
N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 20 - 45 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 16 h / 90 °C

3.1: pyridine / N,N-dimethyl-formamide / 2 h / Cooling with ice

4.1: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

5.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide / 3 h / 70 °C

5.2: pH 3

With pyridine; dmap; hydroxylamine hydrochloride; triethylamine; lithium hydroxide; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.003