Technology Process of N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine
There total 7 articles about N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-butyryl-N-[(2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl]-L-valine methyl ester;
With
lithium hydroxide;
In
methanol; water; N,N-dimethyl-formamide;
at 70 ℃;
for 3h;
With
hydrogenchloride;
In
methanol; water; N,N-dimethyl-formamide;
pH=3;
DOI:10.1016/j.bmc.2012.02.003
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / N,N-dimethyl-formamide / 2 h / Cooling with ice
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux
3.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide / 3 h / 70 °C
3.2: pH 3
With
pyridine; lithium hydroxide;
In
methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.003
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; triethylamine / dichloromethane / 20 - 45 °C / Inert atmosphere
2.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 16 h / 90 °C
3.1: pyridine / N,N-dimethyl-formamide / 2 h / Cooling with ice
4.1: 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux
5.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide / 3 h / 70 °C
5.2: pH 3
With
pyridine; dmap; hydroxylamine hydrochloride; triethylamine; lithium hydroxide;
In
methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.003