Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine

Base Information

• Chemical Name: Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine
• CAS No.: 169129-62-8
• Molecular Formula: C₃₀H₂₈N₂O₂S
• Molecular Weight: 480.631
• Mol file: 169129-62-8.mol

Synonyms:Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine

Chemical Property of Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine

There total 3 articles about Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tryptamine (61-54-1) → Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine (169129-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / BH₃*THF, TFA / tetrahydrofuran

2: toluene / Heating

3: Et₃N / tetrahydrofuran

With borane-THF; triethylamine; trifluoroacetic acid; In tetrahydrofuran; toluene;

DOI:10.1021/ja00141a004

Reference yield:

3-(2-aminoethyl)-2,3-dihydro-1H-indole (13078-91-6) → Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine (169129-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: Et₃N / tetrahydrofuran

With triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/ja00141a004

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + Benzhydrylidene-[2-(2,3-dihydro-1H-indol-3-yl)-ethyl]-amine (169129-61-7) → Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine (169129-62-8)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1021/ja00141a004

upstream raw materials:

p-toluenesulfonyl chloride

Benzhydrylidene-[2-(2,3-dihydro-1H-indol-3-yl)-ethyl]-amine

tryptamine

3-(2-aminoethyl)-2,3-dihydro-1H-indole

Downstream raw materials:

2-[1-(Toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethylamine