(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Base Information

Chemical Name:(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate
CAS No.:530146-91-9
Molecular Formula:C₂₁H₃₀O₃S
Molecular Weight:362.533
Hs Code.:

Synonyms:(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Suppliers and Price of (2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

There total 2 articles about (2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98-59-9
p-toluenesulfonyl chloride

: 530146-87-3
(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propan-1-ol

: 530146-91-9
(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1039/b209147j

Reference yield:

: 2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propionitrile

: 530146-91-9
(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / DIBAL-H / diethyl ether; hexane; toluene / -78 - 0 °C

2: 92 percent / pyridine / 0 °C

With pyridine; diisobutylaluminium hydride; In diethyl ether; hexane; toluene;
DOI:10.1039/b209147j

Reference yield:

: 530146-91-9
(2S)-2-((1R,8aR)-8a-methyl-1,2,3,4,6,7,8,8a-octahydro-1-naphthyl)propyl p-toluenesulfonate

: (1R,3S)-5-[2-[(1R,4aS,8aR)-1-((1R)-5-hydroxy-1,5-dimethylhexyl)-8a-methyl-1,2,3,4,4a,7,8,8a-octahydro-5-naphthyl]ethyl]cyclohex-4-ene-1,3-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: borane-tetrahydrofuran complex / tetrahydrofuran / -20 °C

1.2: NaOH; H₂O₂ / tetrahydrofuran; H₂O / -30 - 20 °C

2.1: 93 percent / sodium iodide / acetone / 60 °C

3.1: pyridine; zinc; NiCl₂ / 0.75 h / 65 °C

3.2: 86 percent / pyridine / 1.5 h / 20 °C

4.1: 93 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

5.1: pyridinium dichromate / CH₂Cl₂ / 20 °C

6.1: 88 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

7.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 2.75 h / -78 - 20 °C

7.2: 81 percent / tetrahydrofuran / 4.17 h / -78 - 20 °C

8.1: 91 percent / CuI; Et₂NH / Pd(PPh₃)2(OAc)2 / acetonitrile / 1 h / 20 °C

9.1: H₂; quinoline / Lindlar catalyst / ethyl acetate; pentane / 20 °C

10.1: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / 20 °C

With pyridine; 1H-imidazole; quinoline; copper(l) iodide; dipyridinium dichromate; n-butyllithium; borane-THF; tetrabutyl ammonium fluoride; hydrogen; diethylamine; diisopropylamine; sodium iodide; nickel dichloride; zinc; Lindlar's catalyst; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; acetone; acetonitrile; pentane;
DOI:10.1039/b209147j