1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

Base Information

Chemical Name:1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine
CAS No.:639089-24-0
Molecular Formula:C₂₄H₃₀N₂O₃S
Molecular Weight:426.58
Hs Code.:

Synonyms:1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

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Chemical Property of 1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

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Technology Process of 1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

There total 4 articles about 1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2859-67-8
3-(3-pyridyl)propan-1-ol

: 639089-24-0
1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂ / Pd/C; Rh/C / 2 h / 76000 Torr

2: 83 percent / K₂CO₃ / ethanol / 2 h / Heating

3: 63 percent / (COCl)2; DMSO / CH₂Cl₂ / 0.75 h / -60 °C

4: NaCN / ethanol / 2 h

With oxalyl dichloride; sodium cyanide; hydrogen; potassium carbonate; dimethyl sulfoxide; palladium on activated charcoal; Rh on carbon; In ethanol; dichloromethane;
DOI:10.1021/jm030905y

Reference yield:

: 639089-20-6
3-(1-benzyl-piperidin-3-yl)-propan-1-ol

: 639089-24-0
1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / (COCl)2; DMSO / CH₂Cl₂ / 0.75 h / -60 °C

2: NaCN / ethanol / 2 h

With oxalyl dichloride; sodium cyanide; dimethyl sulfoxide; In ethanol; dichloromethane;
DOI:10.1021/jm030905y

Reference yield:

: 3-piperidin-3-yl-propan-1-ol; compound with acetic acid

: 639089-24-0
1-benzyl-3-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / K₂CO₃ / ethanol / 2 h / Heating

2: 63 percent / (COCl)2; DMSO / CH₂Cl₂ / 0.75 h / -60 °C

3: NaCN / ethanol / 2 h

With oxalyl dichloride; sodium cyanide; potassium carbonate; dimethyl sulfoxide; In ethanol; dichloromethane;
DOI:10.1021/jm030905y