methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate
CAS No.:1616257-26-1
Molecular Formula:C₁₇H₂₄ClNO₃Si
Molecular Weight:353.921
Hs Code.:

Synonyms:methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

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Chemical Property of methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

Chemical Property:

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Technology Process of methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

There total 6 articles about methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616257-25-0
methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-iodobenzoate

: 1066-54-2
trimethylsilylacetylene

: 1616257-26-1
methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In toluene; at 60 - 70 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 2457-76-3
4-amino-2-chlorobenzoic acid

: 1616257-26-1
methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: acetyl chloride / 5 h / Reflux

2: iodine; silver sulfate / ethanol / 0.25 h / Inert atmosphere

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium hydroxide / acetonitrile / 1 h / 70 °C / Inert atmosphere; Sealed tube

4: hydrogen; platinum(IV) oxide / ethanol / 3 h

5: iodine; silver sulfate / ethanol / 1 h / 20 °C / Inert atmosphere

6: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / 60 - 70 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; iodine; palladium diacetate; silver sulfate; triethylamine; acetyl chloride; triphenylphosphine; potassium hydroxide; In ethanol; toluene; acetonitrile;

Reference yield:

: 1616257-23-8
methyl 4-amino-2-chloro-5-(2-ethoxyvinyl)benzoate

: 1616257-26-1
methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; platinum(IV) oxide / ethanol / 3 h

2: iodine; silver sulfate / ethanol / 1 h / 20 °C / Inert atmosphere

3: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / 60 - 70 °C / Inert atmosphere

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; iodine; silver sulfate; triethylamine; triphenylphosphine; In ethanol; toluene;