N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide

Base Information

• Chemical Name: N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide
• CAS No.: 527716-94-5
• Molecular Formula: C₃₈H₄₀F₂N₄O₄
• Molecular Weight: 654.757

Synonyms:N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide

Chemical Property of N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide

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Technology Process of N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide

There total 1 articles about N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N₃,N₃-dipropylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[3-[(dipropylamino)-carbonyl]-5-(1,3-oxazol-2-yl)] benzoic acid (597563-26-3) + (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(3-ethynylphenyl)cyclopropyl]amino}butan-2-ol → N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide (527716-94-5)

Guidance literature:

1-[3-[(dipropylamino)-carbonyl]-5-(1,3-oxazol-2-yl)] benzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 - 25 ℃; for 1h;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(3-ethynylphenyl)cyclopropyl]amino}butan-2-ol; In tetrahydrofuran; at -35 - 0 ℃; for 1h;

upstream raw materials:

1-[3-[(dipropylamino)-carbonyl]-5-(1,3-oxazol-2-yl)] benzoic acid

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