6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

Base Information

Chemical Name:6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil
CAS No.:149340-98-7
Molecular Formula:C₂₃H₂₅N₅O₅
Molecular Weight:451.482
Hs Code.:

Synonyms:6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

Chemical Property:

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Technology Process of 6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

There total 7 articles about 6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 149340-97-6
6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-3-propyluracil

: 149340-98-7
6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

Guidance literature:: With hydrogenchloride; sodium nitrite; In ethanol; at 30 ℃; for 0.5h;
DOI:10.1021/jm00069a009

Reference yield:

: 24954-67-4
2-(p-nitrophenyl)ethylamine

: 149340-98-7
6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / toluene / 2 h / Ambient temperature

2: 20 percent / acetic anhydride / 2 h / 75 °C

3: 90 percent / 1N aq. NaOH / 0.5 h / 75 °C

4: 87 percent / H₂ / 10percent Pd/C / 8 h

5: 98 percent / NaHCO₃ / tetrahydrofuran; H₂O; toluene / 0.5 h

6: 82 percent / NaNO₂, aq. HCl / ethanol / 0.5 h / 30 °C

With hydrogenchloride; sodium hydroxide; hydrogen; acetic anhydride; sodium hydrogencarbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jm00069a009

Reference yield:

: 149340-93-2
1-(4-nitrophenethyl)-3-propylurea

: 149340-98-7
6-amino-1-<4-<(benzyloxycarbonyl)amino>phenethyl>-5-nitroso-3-propyluracil

Guidance literature:: Multi-step reaction with 5 steps

1: 20 percent / acetic anhydride / 2 h / 75 °C

2: 90 percent / 1N aq. NaOH / 0.5 h / 75 °C

3: 87 percent / H₂ / 10percent Pd/C / 8 h

4: 98 percent / NaHCO₃ / tetrahydrofuran; H₂O; toluene / 0.5 h

5: 82 percent / NaNO₂, aq. HCl / ethanol / 0.5 h / 30 °C

With hydrogenchloride; sodium hydroxide; hydrogen; acetic anhydride; sodium hydrogencarbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jm00069a009