1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Base Information

Chemical Name:1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone
CAS No.:489466-58-2
Molecular Formula:C₂₃H₃₃NO₂Si
Molecular Weight:383.606
Hs Code.:

Synonyms:1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Suppliers and Price of 1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

There total 7 articles about 1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 489466-56-0
3-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-3-oxo-2-o-tolylpropionic acid methyl ester

: 489466-58-2
1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Guidance literature:: With water; sodium chloride; In dimethyl sulfoxide; at 150 ℃; for 0.5h;
DOI:10.1021/jo026411a

Reference yield:

: 229184-01-4
3-bromo-4-[3-hydroxypropyl]pyridine

: 489466-58-2
1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / imidazole / CH₂Cl₂ / 17 h / 20 °C

2: 88 percent / N-ethyldiisopropylamine; 1,3-bis(diphenylphosphino)propane / palladium(II) acetate / dimethylformamide / 20 h / 20 - 95 °C

3: 89 percent / potassium trimethylsilanolate / diethyl ether / 48 h / 20 °C

4: dimethylformamide / 1.5 h / 50 °C

5: 1.69 g / 60percent sodium hydride / dimethylformamide / 3.25 h / -10 - 20 °C

6: 76 percent / sodium chloride; water / dimethylsulfoxide / 0.5 h / 150 °C

With 1H-imidazole; 1,3-bis-(diphenylphosphino)propane; potassium trimethylsilonate; water; N-ethyl-N,N-diisopropylamine; sodium chloride; palladium diacetate; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 5: Claisen condensation;
DOI:10.1021/jo026411a

Reference yield:

: 3430-22-6
3-Bromo-4-methylpyridin

: 489466-58-2
1-{4-[3-(tert-butyldimethylsilanyloxy)propyl]pyridin-3-yl}-2-o-tolylethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.75 h / 5 - 50 °C

1.2: 78 percent / tetrahydrofuran; hexane / 0.5 h / -20 - 0 °C

2.1: 100 percent / imidazole / CH₂Cl₂ / 17 h / 20 °C

3.1: 88 percent / N-ethyldiisopropylamine; 1,3-bis(diphenylphosphino)propane / palladium(II) acetate / dimethylformamide / 20 h / 20 - 95 °C

4.1: 89 percent / potassium trimethylsilanolate / diethyl ether / 48 h / 20 °C

5.1: dimethylformamide / 1.5 h / 50 °C

6.1: 1.69 g / 60percent sodium hydride / dimethylformamide / 3.25 h / -10 - 20 °C

7.1: 76 percent / sodium chloride; water / dimethylsulfoxide / 0.5 h / 150 °C

With 1H-imidazole; n-butyllithium; 1,3-bis-(diphenylphosphino)propane; potassium trimethylsilonate; water; diisopropylamine; N-ethyl-N,N-diisopropylamine; sodium chloride; palladium diacetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: Claisen condensation;
DOI:10.1021/jo026411a