(S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

Base Information

Chemical Name:(S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile
CAS No.:1630982-19-2
Molecular Formula:C₁₅H₁₇F₃N₂O₂
Molecular Weight:314.307
Hs Code.:

Synonyms:(S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

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Chemical Property of (S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

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Technology Process of (S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

There total 2 articles about (S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 871090-34-5
tert-butyl 4-(trifluoromethyl)benzylidenecarbamate

: 32083-60-6
2-(naphthalene-2-ylsulfonyl)acetonitrile

: 1630982-19-2
(S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

Guidance literature:: tert-butyl 4-(trifluoromethyl)benzylidenecarbamate; 2-(naphthalene-2-ylsulfonyl)acetonitrile; With C₄₂H₄₉N₅O₄; In dichloromethane; at -40 ℃; Inert atmosphere;

With chloro-trimethyl-silane; magnesium; ethylene dibromide; In methanol; dichloromethane; at 0 - 20 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201304877

Reference yield:

: 871090-34-5
tert-butyl 4-(trifluoromethyl)benzylidenecarbamate

: 32083-60-6
2-(naphthalene-2-ylsulfonyl)acetonitrile

: 1630982-19-2
(S)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

: (R)-3-(N-tert-butoxycarbonylamine)-3-(4-trifluoromethylphenyl)propanenitrile

Guidance literature:: tert-butyl 4-(trifluoromethyl)benzylidenecarbamate; 2-(naphthalene-2-ylsulfonyl)acetonitrile; With (9H-fluoren-9-yl)methyl ((S)-1-(3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)ureido)-2,2-dimethylpropyl)carbamate; In dichloromethane; at -40 ℃; Inert atmosphere;

With chloro-trimethyl-silane; magnesium; ethylene dibromide; In methanol; dichloromethane; at 0 - 20 ℃; Overall yield = 70 %; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201304877