1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE

Base Information

• Chemical Name: 1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE
• CAS No.: 278603-80-8
• Molecular Formula: C8H14 O2
• Molecular Weight: 142.198
• Mol file: 278603-80-8.mol

Synonyms:Cyclopropane,1-ethenyl-1-(2-methoxyethoxy);1-(2-methoxyethoxy)-1-vinylcyclopropane;

Chemical Property of 1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE

Chemical Property:

• Refractive Index: n20/D 1.441
• Boiling Point: 157.3±23.0 °C(Predicted)
• Flash Point: 114 °C
• PSA: 18.46000
• Density: 0.922 g/mL at 25 °C
• LogP: 1.36800

Purity/Quality:

97% ^*data from raw suppliers

1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 10-22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-(2-Methoxyethoxy)-1-vinylcyclopropane can be used as a useful scaffold for the preparation of 7-membered and bicyclic ring systems.

Technology Process of 1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE

There total 2 articles about 1-(2-METHOXYETHOXY)-1-VINYLCYCLOPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

diiodomethane (75-11-6) + 2-(2-methoxyethoxy)-1,3-butadiene → 1-(2-methoxyethoxy)-1-vinylcyclopropane (278603-80-8)

Guidance literature:

With acetyl chloride; copper(l) chloride; zinc; In diethyl ether; for 3h; Heating;

DOI:10.1021/ol0058691

Reference yield:

4-bromo-3-(2-methoxy-ethoxy)-but-1-ene → 1-(2-methoxyethoxy)-1-vinylcyclopropane (278603-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / 2-methoxy-ethanol / 20 - 90 °C

2: 53 percent / zinc; acetyl chloride; copper(I) chloride / diethyl ether / 3 h / Heating

With potassium hydroxide; acetyl chloride; copper(l) chloride; zinc; In diethyl ether; 2-methoxy-ethanol; 1: Dehydrobromination / 2: Cycloaddition;

DOI:10.1021/ol0058691

Reference yield: 98.0%

1-ethenylcyclohexene (931-49-7) + 1-(2-methoxyethoxy)-1-vinylcyclopropane (278603-80-8) → 4-cyclohex-1-enylcyclohept-4-enone

Guidance literature:

di(rhodium)tetracarbonyl dichloride; In 1,1,2,2-tetrachloroethane; at 20 ℃; for 4h;

DOI:10.1002/1521-3773(20011015)40:20<3895::AID-ANIE3895>3.0.CO;2-#

upstream raw materials:

diiodomethane

Downstream raw materials:

cyclohept-4-en-1-one

5-acetyl-4-ethyl-3a-hydroxy-3,3a,6,6a-tetrahydro-2H-pentalen-1-one

Refernces