1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Base Information

Chemical Name:1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one
CAS No.:858676-71-8
Molecular Formula:C₆₃H₇₈O₁₀Si
Molecular Weight:1023.39
Hs Code.:

1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Synonyms:1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Suppliers and Price of 1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

There total 11 articles about 1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858676-55-8
(2'R,4'S,6'R)-3-(2'-phenyl-6'-(2-benzyldimethylsilylethenyl)-[1,3]dioxan-4'-yl)propan-2-one

: 858676-69-4
((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-Methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-acetaldehyde

: 858676-71-8
1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

: 1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Guidance literature:: (2'R,4'S,6'R)-3-(2'-phenyl-6'-(2-benzyldimethylsilylethenyl)-[1,3]dioxan-4'-yl)propan-2-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; at -72 ℃; for 0.333333h;

((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-Methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-acetaldehyde; In diethyl ether; dichloromethane; at -72 ℃; for 8h;
DOI:10.1021/ja052226d

Reference yield:

: 858676-59-2
(2E)-3-[benzyl(dimethyl)silyl]acrylaldehyde

: 858676-71-8
1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / SiCl₄; diisopropylethylamine; (R,R)-bisphosphoramide / CH₂Cl₂ / 3 h / -70 °C

2.1: 74 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

3.1: 87 percent / i-PrMgCl / tetrahydrofuran / -20 °C

4.1: 90 percent / MeMgBr / diethyl ether / 0 - 20 °C

5.1: DIPEA; Bu₂BOTf / diethyl ether / 0.33 h / -72 °C

5.2: diethyl ether; CH₂Cl₂ / 8 h / -72 °C

With tetrachlorosilane; (R,R)-bisphosphoramide; di-n-butylboryl trifluoromethanesulfonate; methylmagnesium bromide; isopropylmagnesium chloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja052226d

Reference yield:

: 858676-57-0
(5R)-ethyl-7-benzyldimethylsilyl-5-hydroxy-hepta-2,6-dienoate

: 858676-71-8
1-{6-[2-(benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-4-hydroxy-5-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-pentan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 74 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

2.1: 87 percent / i-PrMgCl / tetrahydrofuran / -20 °C

3.1: 90 percent / MeMgBr / diethyl ether / 0 - 20 °C

4.1: DIPEA; Bu₂BOTf / diethyl ether / 0.33 h / -72 °C

4.2: diethyl ether; CH₂Cl₂ / 8 h / -72 °C

With di-n-butylboryl trifluoromethanesulfonate; methylmagnesium bromide; isopropylmagnesium chloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja052226d