(6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem

Base Information

• Chemical Name: (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem
• CAS No.: 79799-39-6
• Molecular Formula: C₂₀H₁₇N₃O₅S
• Molecular Weight: 411.438
• Mol file: 79799-39-6.mol

Synonyms:(6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem

Chemical Property of (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem

There total 6 articles about (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

p-nitrobenzyl-<4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl>-3-anilino but-2-enoate (79799-38-5) → (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem (79799-39-6)

Guidance literature:

With silver(I) acetate; In benzene; Heating;

DOI:10.1016/S0040-4020(01)90532-0

Reference yield: 62.0%

4-Nitrobenzyl-2-[4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl]-3-anilino crotonate → (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem (79799-39-6)

Guidance literature:

With silver(I) acetate; In benzene; Heating;

DOI:10.1039/c39810001269

Reference yield:

p-nitrobenzyl-<4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl>-3-methylsulphonyloxy but-2-enoate (71367-56-1) → (6R)-3-methyl-2-phenyl-4-(p-nitrobenzyloxycarbonyl)-2-azacephem (79799-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / diazabicyclo-<2.2.2>-octane / CH₂Cl₂ / 1 h

2: 62 percent / silver acetate / benzene / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; silver(I) acetate; In dichloromethane; benzene;

DOI:10.1016/S0040-4020(01)90532-0

upstream raw materials:

p-nitrobenzyl-<4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl>-3-anilino but-2-enoate

4'-nitrobenzyl-2-[4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl]-3-methylsulphonyloxy crotonate

aniline

p-nitrobenzyl-<4R-(2-benzthiazolyldithio)-2-oxo-1-azetidinyl>-3-methylsulphonyloxy but-2-enoate