(Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one

Base Information

• Chemical Name: (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one
• CAS No.: 1359978-86-1
• Molecular Formula: C₂₆H₃₄O₃S
• Molecular Weight: 426.62
• Mol file: 1359978-86-1.mol

Synonyms:(Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one

Chemical Property of (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one

There total 2 articles about (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4,5-dimethoxy-2-(methylthio)phenyl)nonan-1-one (1359978-91-8) + phenylacetylene (536-74-3) → (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one (1359978-86-1)

Guidance literature:

With [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4]; In o-xylene; at 60 ℃; for 2h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja2108992

Reference yield:

n-octyne (629-05-0) + 4,5-dimethoxy-2-(methylthio)benzaldehyde (63624-30-6) → (Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one (1359978-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; bis(dicyclohexylphosphino)methane / acetone / 3 h / 55 °C / Inert atmosphere

2: [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4] / o-xylene / 2 h / 60 °C / Inert atmosphere

With bis(norbornadiene)rhodium(l)tetrafluoroborate; [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4]; hydrogen; bis(dicyclohexylphosphino)methane; In o-xylene; acetone;

DOI:10.1021/ja2108992

Reference yield:

(Z)-1-(4,5-dimethoxy-2-(2-(methylthio)-2-phenylvinyl)phenyl)nonan-1-one (1359978-86-1) → 6,7-dimethoxy-1-octyl-3-phenylisoquinoline

Guidance literature:

With ammonium acetate; acetic acid; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol402650q

upstream raw materials:

1-(4,5-dimethoxy-2-(methylthio)phenyl)nonan-1-one

phenylacetylene

n-octyne

4,5-dimethoxy-2-(methylthio)benzaldehyde