(1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride

Base Information

• Chemical Name: (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride
• CAS No.: 463342-69-0
• Molecular Formula: C₁₅H₁₁ClF₃N₃O
• Molecular Weight: 341.72
• Mol file: 463342-69-0.mol

Synonyms:(1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride

Chemical Property of (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride

There total 3 articles about (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-chloro-3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide (106878-54-0) + aniline (62-53-3) → (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride (463342-69-0)

Guidance literature:

aniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

2-chloro-3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide; With sodium acetate; In methanol; water; at 5 - 10 ℃; for 2h; Further stages.;

DOI:10.1002/1099-0690(200205)2002:10<1654::AID-EJOC1654>3.0.CO;2-U

Reference yield:

3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide (785-74-0) → (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride (463342-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SO₂Cl₂ / toluene

2.1: HCl; sodium nitrite / H₂O / 0 - 5 °C

2.2: 66 percent / sodium acetate / methanol; H₂O / 2 h / 5 - 10 °C

With hydrogenchloride; sulfuryl dichloride; sodium nitrite; In water; toluene; 2.2: Japp-Klingemann reaction;

DOI:10.1002/1099-0690(200205)2002:10<1654::AID-EJOC1654>3.0.CO;2-U

Reference yield:

3-trifluoromethylaniline (98-16-8) → (1Z)-2-oxo-N-phenyl-2-{[3-(trifluoromethyl)phenyl]amino}ethanehydrazonoyl chloride (463342-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 150 - 160 °C

2.1: SO₂Cl₂ / toluene

3.1: HCl; sodium nitrite / H₂O / 0 - 5 °C

3.2: 66 percent / sodium acetate / methanol; H₂O / 2 h / 5 - 10 °C

With hydrogenchloride; sulfuryl dichloride; sodium nitrite; In water; toluene; 3.2: Japp-Klingemann reaction;

DOI:10.1002/1099-0690(200205)2002:10<1654::AID-EJOC1654>3.0.CO;2-U

upstream raw materials:

2-chloro-3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide

aniline

3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide

3-trifluoromethylaniline