(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

Base Information

Chemical Name:(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol
CAS No.:137871-08-0
Molecular Formula:C₃₆H₄₈O₅Si
Molecular Weight:588.86
Hs Code.:

Synonyms:(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

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Chemical Property of (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

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Technology Process of (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

There total 7 articles about (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137871-07-9
5(S)-<<(tert-Butyldiphenylsilyl)oxy>methyl>-3-<1-<4(S)-<5(R)-ethyl-6(R)-methyl-2(S)-phenyldioxanyl>>methyl>-4(R)-methyldihydro-2(3H)-furanone

: 137871-08-0
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃; for 1h;
DOI:10.1021/jo00023a017

Reference yield:

: 137871-06-8
(Z)-5(S)-<<(tert-Butyldiphenylsilyl)oxy>methyl>-3-<<4(S)-<5(R)-ethyl-6(R)-methyl-2(S)-phenyldioxanyl>>methylene>-4(R)-methyldihydro-2(3H)-furanone

: 137871-08-0
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 29.06 mg / CuI, Red-Al, 2-butanol / tetrahydrofuran / 1) -78 deg C, 30 min, 2) -20 deg C, 2 h

2: DIBAL / diethyl ether / 1 h / -78 °C

With copper(l) iodide; diisobutylaluminium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00023a017

Reference yield:

: 137871-04-6,137941-10-7
5(S)-<<(tert-Butyldiphenylsilyl)oxy>methyl>-3-<1-hydroxy-1-<4(S)-<5(R)-ethyl-6(R)-methyl-2(S)-phenyldioxanyl>>methyl>-4(R)-methyldihydro-2(3H)-furanone

: 137871-08-0
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-((2S,4R,5R,6R)-5-ethyl-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-4-methyl-tetrahydro-furan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 1.25 h / -10 °C

2: 98 percent / DBU / benzene / 12 h / Ambient temperature

3: 29.06 mg / CuI, Red-Al, 2-butanol / tetrahydrofuran / 1) -78 deg C, 30 min, 2) -20 deg C, 2 h

4: DIBAL / diethyl ether / 1 h / -78 °C

With copper(l) iodide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo00023a017