2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

Base Information

• Chemical Name: 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile
• CAS No.: 1192885-47-4
• Molecular Formula: C₁₈H₁₅ClN₄O
• Molecular Weight: 338.796
• Mol file: 1192885-47-4.mol

Synonyms:2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

Chemical Property of 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

There total 6 articles about 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodoacetonitrile (624-75-9) + 2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine (1192885-45-2) → 2-(4-(2-chloropyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-49-6) + 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-47-4)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

DOI:10.1016/j.bmcl.2009.08.029

Reference yield:

3-hydroxy-5-methylbenzoic acid (585-81-9) → 2-(4-(2-chloropyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-49-6) + 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-47-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: 12 h / Reflux

3.2: 2 h / 20 °C

4.1: potassium carbonate / acetone / 2 h / Reflux

4.2: 2 h / Reflux

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;

Reference yield:

methyl 3-methoxy-5-methylbenzoate (108593-44-8) → 2-(4-(2-chloropyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-49-6) + 2-(4-(2-chloropyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile (1192885-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: 12 h / Reflux

2.2: 2 h / 20 °C

3.1: potassium carbonate / acetone / 2 h / Reflux

3.2: 2 h / Reflux

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetone;

upstream raw materials:

iodoacetonitrile

2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine

3-hydroxy-5-methylbenzoic acid

2-chloro-4-picoline