N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

Base Information

Chemical Name:N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester
CAS No.:112858-98-7
Molecular Formula:C₂₃H₂₈N₄O₅
Molecular Weight:440.499
Hs Code.:

Synonyms:N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

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Chemical Property of N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

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Technology Process of N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

There total 6 articles about N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(3-Formyl-4-nitro-phenoxy)-butyric acid methyl ester

: 112858-98-7
N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) EtONa / 1.) ethanol, 10 min, 2.) ethanol, 2 h

2: H₂ / 10 percent Pd/C / dimethylformamide / 3102.9 Torr

3: I₂ / methanol / 0.5 h / Heating

4: 88 percent / 4 N NaOH / methanol; H₂O / 1 h / Ambient temperature

5: DPPA, Et₃N, DMAP / dimethylformamide / Ambient temperature

With dmap; sodium hydroxide; diphenyl-phosphinic acid; hydrogen; iodine; sodium ethanolate; triethylamine; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a019

Reference yield:

: 4-{3-[2,5-Dioxo-imidazolidin-(4Z)-ylidenemethyl]-4-nitro-phenoxy}-butyric acid methyl ester

: 112858-98-7
N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd/C / dimethylformamide / 3102.9 Torr

2: I₂ / methanol / 0.5 h / Heating

3: 88 percent / 4 N NaOH / methanol; H₂O / 1 h / Ambient temperature

4: DPPA, Et₃N, DMAP / dimethylformamide / Ambient temperature

With dmap; sodium hydroxide; diphenyl-phosphinic acid; hydrogen; iodine; triethylamine; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a019

Reference yield:

: 4-[4-Amino-3-(2,5-dioxo-imidazolidin-4-ylmethyl)-phenoxy]-butyric acid methyl ester

: 112858-98-7
N-cyclohexyl-N-[4-[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]-1-oxobutyl]glycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: I₂ / methanol / 0.5 h / Heating

2: 88 percent / 4 N NaOH / methanol; H₂O / 1 h / Ambient temperature

3: DPPA, Et₃N, DMAP / dimethylformamide / Ambient temperature

With dmap; sodium hydroxide; diphenyl-phosphinic acid; iodine; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a019