rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

Base Information

• Chemical Name: rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine
• CAS No.: 1380507-30-1
• Molecular Formula: C₁₄H₁₇N₃O
• Molecular Weight: 243.308
• Mol file: 1380507-30-1.mol

Synonyms:rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

Chemical Property of rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

There total 4 articles about rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-methyl-2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one (1380507-29-8) → rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine (1380507-30-1)

Guidance literature:

6-methyl-2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 60h; Inert atmosphere;

With Glauber's salt; In tetrahydrofuran; ethyl acetate; at 0 ℃; for 0.25h;

Reference yield:

1-(2-((tert-butoxycarbonyl)amino)ethyl)-3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester (1380507-28-7) → rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine (1380507-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 72 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 60 h / 0 - 20 °C / Inert atmosphere

2.2: 0.25 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

2,4-dioxo-5-phenoxypentanoic acid ethyl ester (856256-81-0) → rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine (1380507-30-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 16 h / 80 °C

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 120 °C / microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 72 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 60 h / 0 - 20 °C / Inert atmosphere

4.2: 0.25 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol;

upstream raw materials:

2,4-dioxo-5-phenoxypentanoic acid ethyl ester

3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester

1-(2-((tert-butoxycarbonyl)amino)ethyl)-3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester

6-methyl-2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one