benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

Base Information

Chemical Name:benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS No.:130611-88-0
Molecular Formula:C₃₂H₃₄N₂O₄
Molecular Weight:510.633
Hs Code.:

Synonyms:benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

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Chemical Property of benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

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Technology Process of benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

There total 5 articles about benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 51089-83-9
benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 123401-77-4
benzyl 7-acetoxy-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

: 130611-88-0
benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

Guidance literature:: toluene-4-sulfonic acid;
DOI:10.1016/S0040-4039(00)88464-6

Reference yield:

: 123401-76-3
benzyl 3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

: 130611-88-0
benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / acetic anhydride / acetic acid / 2 h / 20 °C

2: 73 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With acetic anhydride; toluene-4-sulfonic acid; In acetic acid; 1: Acetoxylation / 2: Condensation;
DOI:10.1016/S0040-4020(97)10288-5

Reference yield:

: 5396-89-4
benzyl acetoacetate

: 130611-88-0
benzyl 7-(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: conc. HCl; sodium nitrite / H₂O / salt/ice cooling

1.2: 91 percent / sodium acetate / H₂O; ethanol / 1.5 h / 0 - 20 °C

2.1: 44 percent / sodium acetate; zinc / acetic acid / 100 - 110 °C

3.1: 86 percent / acetic anhydride / acetic acid / 2 h / 20 °C

4.1: 73 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With hydrogenchloride; sodium acetate; acetic anhydride; toluene-4-sulfonic acid; zinc; sodium nitrite; In water; acetic acid; 1.1: Diazotization / 1.2: Condensation / 2.1: Knorr condensation / 3.1: Acetoxylation / 4.1: Condensation;
DOI:10.1016/S0040-4020(97)10288-5