2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Base Information

Chemical Name:2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine
CAS No.:929722-01-0
Molecular Formula:C₂₄H₃₅NO₄SSi
Molecular Weight:461.698
Hs Code.:

2-benzyloxymethyl-3-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Synonyms:2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Suppliers and Price of 2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

There total 4 articles about 2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1099592-54-7
C₁₇H₂₉N₃O₃Si

: 929722-00-9
C₁₇H₂₉N₃O₃Si

: 98-59-9
p-toluenesulfonyl chloride

: 929722-01-0
2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: C₁₇H₂₉N₃O₃Si; C₁₇H₂₉N₃O₃Si; With triphenylphosphine; In toluene; for 5h; Heating / reflux;

p-toluenesulfonyl chloride; With triethylamine; In toluene; at 0 - 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 81028-03-7
(Z)-4-benzyloxy-but-2-en-1-ol

: 929722-01-0
2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: molecular sieves; t-BuOOH / diethyl (-)-tartrate; Ti(O-iPr)4 / CH₂Cl₂; toluene / 13 h / -23 - -12 °C

2.1: imidazole / dimethylformamide / 20 °C

3.1: NaN₃; NH₄Cl / H₂O; 2-methoxy-ethanol / 3 h / Heating

3.2: Ph₃P / tetrahydrofuran / 4 h / Heating

3.3: triethylamine / tetrahydrofuran / 20 °C

With 1H-imidazole; tert.-butylhydroperoxide; sodium azide; molecular sieve; ammonium chloride; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; In dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1021/ja065833p

Reference yield:

: 929721-99-3
(3-benzyloxymethyl-oxiranylmethoxy)-tert-butyl-dimethyl-silane

: 98-59-9
p-toluenesulfonyl chloride

: 929722-01-0
2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: (3-benzyloxymethyl-oxiranylmethoxy)-tert-butyl-dimethyl-silane; With sodium azide; ammonium chloride; In 2-methoxy-ethanol; water; for 3h; Heating;

With triphenylphosphine; In tetrahydrofuran; for 4h; Heating;

p-toluenesulfonyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja065833p