Technology Process of N-benzyl-4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
There total 2 articles about N-benzyl-4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(5-bromo-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one;
With
1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine;
In
dimethyl sulfoxide;
at 70 ℃;
for 3h;
Inert atmosphere;
Microwave irradiation;
With
N-chloro-succinimide;
In
tetrahydrofuran;
at 23 ℃;
for 1.5h;
Inert atmosphere;
benzylamine;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 23 ℃;
for 20h;
chemoselective reaction;
Inert atmosphere;
DOI:10.1021/ol403072r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium bromide; Oxone / water; acetone / 2 h / 23 °C
2.1: potassium pyrosulfite; sodium formate; palladium diacetate; triphenylphosphine; 1,10-Phenanthroline; tetraethylammonium bromide / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere; Microwave irradiation
2.2: 1.5 h / 23 °C / Inert atmosphere
2.3: 20 h / 23 °C / Inert atmosphere
With
Oxone; 1,10-Phenanthroline; potassium pyrosulfite; tetraethylammonium bromide; sodium formate; palladium diacetate; triphenylphosphine; potassium bromide;
In
water; dimethyl sulfoxide; acetone;
DOI:10.1021/ol403072r