13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

Base Information

Chemical Name:13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III
CAS No.:345983-44-0
Molecular Formula:C₄₃H₆₁NO₁₅
Molecular Weight:831.955
Hs Code.:

Synonyms:13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

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Chemical Property of 13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

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Technology Process of 13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

There total 11 articles about 13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 345983-43-9
13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-triethylsilyloxy-5'-methylhexanoate]-9(R)-dihydro-7,9-isopropylidene-baccatin-III

: 345983-44-0
13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

Guidance literature:: With hydrogenchloride; In methanol; at 40 ℃; for 13h;
DOI:10.1021/jo0057203

Reference yield:

: C₅₃H₈₃NO₁₆Si

: 345983-44-0
13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

Guidance literature:: With hydrogenchloride; In ethanol; at 0 ℃; for 3h; Yield given;
DOI:10.1021/jm00043a005

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 345983-44-0
13-[(2'R,3'S)-3'-(N-tert-butoxycarbonyl)amino-2'-hydroxy-5'-methylhexanoate]-9(R)-dihydro-baccatin-III

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; DMAP / CH₂Cl₂ / 1.5 h / 23 °C

2: 95 percent / LiHMDS / tetrahydrofuran / 1.5 h / -40 °C

3: 90 percent / aq. HCl / methanol / 13 h / 40 °C

With hydrogenchloride; dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo0057203