N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

Base Information

Chemical Name:N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine
CAS No.:853730-22-0
Molecular Formula:C₁₈H₂₃F₂NO₅
Molecular Weight:371.381
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

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Chemical Property of N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

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Technology Process of N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

There total 5 articles about N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 853730-21-9
6-azido-3,3-difluoro-2-(2-methoxyethoxymethoxy)-hexa-1,4-diene

: 501-53-1,94274-21-2
benzyl chloroformate

: 853730-22-0
N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

Guidance literature:: 6-azido-3,3-difluoro-2-(2-methoxyethoxymethoxy)-hexa-1,4-diene; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;

With water; In tetrahydrofuran; at 65 ℃; for 16h;

benzyl chloroformate; With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 8h;
DOI:10.1021/jm060066q

Reference yield:

: (E)-4,4-Difluoro-5-(2-methoxy-ethoxymethoxy)-hexa-2,5-dienylamine

: 501-53-1,94274-21-2
benzyl chloroformate

: 853730-22-0
N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 8h;
DOI:10.1021/ol050558h

Reference yield:

: 853730-20-8
3,3-difluoro-4-mesyloxy-2-(2-methoxyethoxymethoxy)-hexa-1,5-diene

: 853730-22-0
N-(benzyloxycarbonyl)-4,4-difluoro-5-(2-methoxyethoxymethoxy)-hexa-2,5-dien-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Pd(PPh₃)4; sodium azide / tetrahydrofuran; H₂O / 10 h / 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

2.2: H₂O / tetrahydrofuran / 16 h / 65 °C

2.3: 90 percent / K₂CO₃ / tetrahydrofuran; H₂O / 8 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1021/jm060066q