(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester
CAS No.:256452-04-7
Molecular Formula:C₄₁H₄₄N₃O₁₃P
Molecular Weight:817.786
Hs Code.:

(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

Synonyms:(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

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Chemical Property of (S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

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Technology Process of (S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

There total 5 articles about (S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₄₄H₄₈N₃O₁₃P

: 256452-04-7
(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

Guidance literature:: With formic acid; acetic anhydride;
DOI:10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2

Reference yield:

: 256451-98-6
C₂₂H₂₂Cl₃NO₅

: 256452-04-7
(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-BBN / tetrahydrofuran

1.2: 65 percent / NaOAc; H₂O₂

2.1: 94 percent / Ph₃P; DIAD / tetrahydrofuran / 0 °C

3.1: 61 percent / Zn / acetic acid

4.1: 85 percent / HCOOH; Ac₂O

With 9-borabicyclo[3.3.1]nonane dimer; formic acid; di-isopropyl azodicarboxylate; acetic anhydride; triphenylphosphine; zinc; In tetrahydrofuran; acetic acid; 1.1: Addition / 1.2: Oxidation / 2.1: Substitution / 3.1: Reduction / 4.1: Ring cleavage;
DOI:10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2

Reference yield:

: 256451-99-7
C₂₂H₂₄Cl₃NO₆

: 256452-04-7
(S)-2-(Benzyloxy-formyl-amino)-5-[(5S,7R,8S,9R)-7-(bis-benzyloxy-phosphoryloxymethyl)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[4.4]non-3-yl]-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Ph₃P; DIAD / tetrahydrofuran / 0 °C

2: 61 percent / Zn / acetic acid

3: 85 percent / HCOOH; Ac₂O

With formic acid; di-isopropyl azodicarboxylate; acetic anhydride; triphenylphosphine; zinc; In tetrahydrofuran; acetic acid; 1: Substitution / 2: Reduction / 3: Ring cleavage;
DOI:10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2