5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

Base Information

Chemical Name:5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide
CAS No.:810685-52-0
Molecular Formula:C₂₈H₂₉Cl₂N₅O₂
Molecular Weight:538.477
Hs Code.:

Synonyms:5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

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Chemical Property of 5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

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Technology Process of 5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

There total 9 articles about 5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₈Cl₃N₃O₂

: 810685-52-0
5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

Guidance literature:: With 1-Aminopiperidine; In toluene; for 24h;

Reference yield:

: 810685-49-5
5,6-bis(4-chlorophenyl)pyrazine-2,3-dicarboxylic acid

: 810685-52-0
5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / Heating / reflux

2: acetonitrile / 0.17 h

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h

4: 1-Aminopiperidine / toluene / 24 h

With oxalyl dichloride; 1-Aminopiperidine; acetyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 3457-46-3,88372-92-3
4,4'-dichlorobenzil

: 810685-52-0
5,6-bis(4-chlorophenyl)-N-piperidin-1-yl-3-(piperidin-1-ylcarbonyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / ethanol / 75 °C

2: potassium hydroxide; dihydrogen peroxide; nonyl alcohol / water / 2 h / Heating / reflux

3: acetyl chloride / Heating / reflux

4: acetonitrile / 0.17 h

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h

6: 1-Aminopiperidine / toluene / 24 h

With potassium hydroxide; oxalyl dichloride; dihydrogen peroxide; 1-Aminopiperidine; acetic acid; acetyl chloride; N,N-dimethyl-formamide; nonyl alcohol; In ethanol; dichloromethane; water; toluene; acetonitrile;