tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate;N-cyclohexylcyclohexanamine

Base Information

• Chemical Name: tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate;N-cyclohexylcyclohexanamine
• CAS No.: 52657-56-4
• Molecular Formula: C23H44N2O3
• Molecular Weight: 412.613
• Mol file: 52657-56-4.mol

Synonyms:EINECS 258-076-8;N-(tert-Butoxycarbonyl)-L-leucine, compound with dicyclohexylamine(1:1)

Chemical Property of tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate;N-cyclohexylcyclohexanamine

Chemical Property:

• Vapor Pressure: 0.00152mmHg at 25°C
• Boiling Point: 295.5°Cat760mmHg
• Flash Point: 132.5°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 396.33519327
• Heavy Atom Count: 28
• Complexity: 334

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C=O)NC(=O)OC(C)(C)C.C1CCC(CC1)NC2CCCCC2
• Isomeric SMILES: CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C.C1CCC(CC1)NC2CCCCC2

Technology Process of tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate;N-cyclohexylcyclohexanamine

There total 1 articles about tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate;N-cyclohexylcyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + N-cyclohexyl-cyclohexanamine (101-83-7) → Boc-Leu-OH*DCHA (52657-56-4)

Guidance literature:

In methanol; at 20 ℃; Sonication;

DOI:10.1002/chem.201200986

Reference yield: 87.0%

N,N'-bis(4-nitrophenyl)phospheneimidous amide (134393-23-0) + Boc-Leu-OH*DCHA (52657-56-4) → N-tert-butoxycarbonyl-L-leucine p-nitroanilide (114684-52-5)

Guidance literature:

With pyridine; at 40 ℃; for 1.5h;

DOI:10.1246/bcsj.64.1422

Reference yield: 60.0%

Boc-Leu-OH*DCHA (52657-56-4) + H-Asp-Ser(Bzl)-Tyr-OMe (96935-94-3) → Boc-Leu-Asp-Ser(Bzl)-Tyr-OMe (96922-23-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 4h;

DOI:10.1248/cpb.33.184

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

N-cyclohexyl-cyclohexanamine

Downstream raw materials:

N-tert-butoxycarbonyl-L-leucine p-nitroanilide

Boc-Leu-Asp-Ser(Bzl)-Tyr-OMe