2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine
• CAS No.: 180900-91-8
• Molecular Formula: C₂₂H₁₅N₃S
• Molecular Weight: 353.447
• Mol file: 180900-91-8.mol

Synonyms:2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine

Chemical Property of 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine

There total 2 articles about 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-naphthyl ketone (93-08-3) → 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine (180900-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine, aluminium chloride / diethyl ether

2: 2.) sodium hydrogen carbonate / 1.) ethanol, reflux, 1 h, 2.) ethanol, reflux, 14 h

With aluminium trichloride; bromine; sodium hydrogencarbonate; In diethyl ether;

DOI:10.1071/ch9960443

Reference yield:

3-amino-6-phenylthiopyridazine (90844-35-2) + 2-Bromo-2'-acetonaphthone (613-54-7) → 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine (180900-91-8)

Guidance literature:

With sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) ethanol, reflux, 1 h, 2.) ethanol, reflux, 14 h;

DOI:10.1071/ch9960443

Reference yield: 79.0%

N-(hydroxymethyl)benzamide (6282-02-6) + 2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazine (180900-91-8) → N-(2-Naphthalen-2-yl-6-phenylsulfanyl-imidazo[1,2-b]pyridazin-3-ylmethyl)-benzamide

Guidance literature:

With sulfuric acid; In acetic acid; for 14h; Heating;

DOI:10.1071/ch9960443 DOI:10.1071/ch9960451

upstream raw materials:

3-amino-6-phenylthiopyridazine

2-Bromo-2'-acetonaphthone

methyl 2-naphthyl ketone