7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

Base Information

Chemical Name:7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide
CAS No.:100448-39-3
Molecular Formula:C₁₅H₁₁ClF₃N₃O₃S
Molecular Weight:405.785
Hs Code.:

Synonyms:7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

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Chemical Property of 7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

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Technology Process of 7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

There total 5 articles about 7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100448-28-0
6-chloro-7-sulfamoyl-2--1-(2H)-phthalazinone

: 100448-39-3
7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

Guidance literature:: With sodium tetrahydroborate; aluminium trichloride; In diethylene glycol dimethyl ether; at 40 ℃; for 0.75h;
DOI:10.1021/jm00156a011

Reference yield:

: 2736-23-4
2,4-dichloro-5-sulfamoylbenzoic acid

: 100448-39-3
7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: 33 percent / dimethylformamide / 2 h / 160 °C

2: 34 percent / AcOH, Zn / methanol / 6 h / 45 °C

3: 54 percent / ethanol; H₂O / 6 h / 85 °C

4: 88 percent / concd. HCl / dimethylformamide / 10 h / 100 °C

5: 72 percent / AlCl₃, NaBH₄ / bis-(2-methoxy-ethyl) ether / 0.75 h / 40 °C

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; acetic acid; zinc; In methanol; ethanol; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a011

Reference yield:

: 3861-99-2
4-chloro-5-sulfamoylphthalimide

: 100448-39-3
7-Chloro-4-oxo-3-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-phthalazine-6-sulfonic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 34 percent / AcOH, Zn / methanol / 6 h / 45 °C

2: 54 percent / ethanol; H₂O / 6 h / 85 °C

3: 88 percent / concd. HCl / dimethylformamide / 10 h / 100 °C

4: 72 percent / AlCl₃, NaBH₄ / bis-(2-methoxy-ethyl) ether / 0.75 h / 40 °C

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; acetic acid; zinc; In methanol; ethanol; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a011